10 Very Rare Disease

1. Ichthyosis

It is a skin disorder wherein there is an excessive amount of dry surfaced scales that happens at an early age. This is hereditary, meaning; it can be passed on to the next generation. It is classified because of the abnormal epidermal differentiation or metabolism, making a person look like a tree.

2. Fibrodysplasia Ossificans Progressive

This is a disorder on connective tissues and muscle tissues like ligaments and tendons, wherein there is a new bone being formed outside the skeletal system that limits the movement of the individual, induces the inability to talk, and limited diet that later would result to malnutrition. The ratio for this disease is 1 out of 2 million people in the world.

3. Argyria

It is strongly characterized with a blue or gray discoloration on the skin, which is caused by an excessive exposure from silver or an ingestion of silver salts, which are found in certain medical prescriptions. People who are prone to have this disease are those who work in mining industries that works on silver extraction and even those who are doing photographic processing.

4. Pica Syndrome

This is a kind of disorder that typically happens to children and pregnant women wherein there is a strong craving to eat non-food substances or materials such as paper or dirty items. This condition is actually associated to a bird called magpie that tends to eat anything. It is really common to women and children. It could be diagnosed as mental autism for the kids, which is believed to be caused by mineral deficiency such as iron.

5. Blaschko Lines

These are skin lines, which cannot be seen under normal situations. It can be seen if there are triggering skin diseases where patterns become apparent or visible at all. It appears on wavy shapes on the head, chest, sides, and stomach. According to studies, it is caused by the migration of the embryonic cells, which are not in line with the human muscular and lymphatic or nervous system. In fact, this is found on animals like dogs and cats.

 6. Moebius Syndrome

It is a neurological disorder where the 6^th to 7^th cranial nerves are affected. It includes the eye and face muscles that results to partial or total facial paralysis. If this occurs to babies, there is a strong inability for the child to be fed through sucking. Some other characteristics of this disease are crossed eyes, inability to move the head, lack of facial expressions, and inability to smile. This happens when the facial nerves are underdeveloped, which is identified to genetic causes that have not yet been proven.

7. Cutaneous horns

These are uncommon keratinous skin tumors, which are in the form of horns. It grows on human feet and hands. In most cases, it is benign. But at times, premalignant or malignant. This happens to adults, especially those who are frequently exposed in the sun and have fair skin where lesions might occur thereafter.

8. Elephantiasis

This is opposite of the Ehlers-Danlos Syndrome wherein there is a thickening process that happens on the skin that most commonly happens in the legs of most males. This is also called as Lymphatic Filariasis, which is actually caused by parasitic worms called Wuchereria Bancrofti, B. Timori, and Brugia Malayi that affects the lymphatic system. This is done through transmission being carried by mosquitoes. It is an extreme case of large inflammation that can be found on the head, torso, and limbs.

9. Ehlers-Danlos Syndrome

The other term for this is Cutis Hyperplastic, which is actually a defect, found in the synthesis of collagen with a group of inherited connective tissue disorders. When collagen is not developed, it affects the right form of the body that would cause human deformity. As another term stated, there is an extensive elasticity occurring on the skin and few of the individuals who are diagnosed of it has very thin skin.

10. Werewolf Syndrome

It is called werewolf because there is an abnormal amount of hair growth on the human body parts such as the face, arms, and hands. Nonetheless, in medical terms, it is called as Hypertrichosis or Ambras Syndrome. It can be classified as localized hypertrichosis or the generalized type. Studies have shown that it can be congenital, which means that an individual has it on his or her genes even before birth or it can be acquired.